Which organ is NOT typically involved in the metastasis of acute lymphocytic leukemia?

Acute lymphocytic leukemia (ALL) is a type of cancer that primarily affects the blood and bone marrow, leading to the proliferation of immature lymphocytes. When considering the spread of ALL, certain organs are more commonly affected due to their vascularization and the nature of the disease.

The brain, spleen, and liver are all well-known sites for the metastasis of ALL. The central nervous system can be involved due to the high blood supply and the potential for leukemic cells to cross the blood-brain barrier. The spleen often becomes enlarged as it is a key organ in the immune response, and leukemic cells may infiltrate it. The liver, which plays pivotal roles in metabolism and detoxification, also often shows involvement in leukemia due to its rich blood supply and ability to harbor leukemic cells.

In contrast, the heart is not typically a site for the metastasis of ALL. While leukemic infiltration can occasionally affect nearly any organ, including the heart in rare cases, it is not considered a primary or common site for metastasis like the others mentioned. The heart's role in this context is more related to complications of illness rather than direct invasion or proliferation of leukemic cells. This prevents it from being categorized alongside the more